abstract：:The technology of array comparative genomic hybridization (array-CGH/aCGH) enabled the identification of novel genomic aberrations in chronic lymphocytic leukemia (CLL) including the monoallelic and biallelic deletions affecting 22q11 locus. In contrast to previous publications, we hypothesized that the described 22q1...

journal_title：Leukemia research

authors： Mraz M,Stano Kozubik K,Plevova K,Musilova K,Tichy B,Borsky M,Kuglik P,Doubek M,Brychtova Y,Mayer J,Pospisilova S

更新日期：2013-07-01 00:00:00

abstract：:CD200, a membrane glycoprotein of the immunoglobulin superfamily, is overexpressed in CLL. Soluble in serum CD200 (sCD200) is correlated with poor prognosis in CLL. ADAM (a disintegrin and metalloproteinase) enzymes are implicated in membrane protein shedding. ADAM28 mRNA expression in CLL was correlated with plasma s...

journal_title：Leukemia research

authors： Twito T,Chen Z,Khatri I,Wong K,Spaner D,Gorczynski R

更新日期：2013-07-01 00:00:00

abstract：:We examined the symptoms and referral rates to specialized palliative care and psychosocial oncology services of patients with acute leukemia. The Memorial Symptom Assessment Scale (MSAS) was completed by 249 adult patients with acute leukemia. Patients reported a median of 9 physical and 2 psychological symptoms, and...

journal_title：Leukemia research

authors： Zimmermann C,Yuen D,Mischitelle A,Minden MD,Brandwein JM,Schimmer A,Gagliese L,Lo C,Rydall A,Rodin G

更新日期：2013-07-01 00:00:00

abstract：:The aim of this study was to evaluate effect of c-KIT mutations on RUNX1/RUNX1T1 fusion transcript expression in patients with t(8;21)-positive AML. Fifty patients diagnosed with t(8;21)-positive AML for recent 10 years were enrolled. Patients with c-KIT mutations tended to achieve a greater than 3-log reduction in RU...

journal_title：Leukemia research

authors： Park SH,Chi HS,Cho YU,Jang S,Park CJ

更新日期：2013-07-01 00:00:00

abstract：:Defective apoptosis is a hallmark of the progression of B chronic lymphocytic leukaemia (B-CLL). Smac-mimetics have been shown to induce apoptosis in several tumours. We describe the in vitro pro-apoptotic activity and regulation of the molecular pathway induced by new Smac-mimetics in B-CLL. The cytotoxic effect was ...

journal_title：Leukemia research

authors： Scavullo C,Servida F,Lecis D,Onida F,Drago C,Ferrante L,Seneci P,Barcellini W,Lionetti M,Todoerti K,Neri A,Delia D,Deliliers GL

更新日期：2013-07-01 00:00:00

abstract：:We conducted an analysis of the effect of monocytosis at diagnosis of CLL on subsequent overall (OS) and treatment-free survival (TFS). Monocyte counts were performed using the Sysmex XE2100 analyser. A monocyte count >0.9 × 10(9)L(-1) at the time of diagnosis was associated with a shortened OS and TFS. Monocytosis at...

journal_title：Leukemia research

authors： Mazumdar R,Evans P,Culpin R,Bailey J,Allsup D

更新日期：2013-06-01 00:00:00

abstract：:Treatment of CMML remains a clinical challenge, with no drug demonstrating clear clinical benefit. Even if azacitidine is approved in the treatment of CMML, its role remains disputed. We report a cohort of 76 CMML patients (according to WHO classification) treated with azacitidine in 3 programs (French AZA compassiona...

journal_title：Leukemia research

authors： Adès L,Sekeres MA,Wolfromm A,Teichman ML,Tiu RV,Itzykson R,Maciejewski JP,Dreyfus F,List AF,Fenaux P,Komrokji RS

更新日期：2013-06-01 00:00:00

abstract：:Discovering genetic predictors of childhood acute lymphoblastic leukemia (ALL) necessitates the evaluation of novel factors including maternal genetic effects, which are a proxy for the intrauterine environment, and robust epidemiologic study designs. Therefore, we evaluated five maternal and offspring xenobiotic meta...

journal_title：Leukemia research

authors： Nousome D,Lupo PJ,Okcu MF,Scheurer ME

更新日期：2013-05-01 00:00:00

abstract：:We evaluated outcomes in two consecutive groups of AML patients age>60 years in CR after 7+3 induction therapy. Group 1 received consolidation with cytarabine 1.5g/m(2) q12h×6+daunorubicin for two cycles, while group 2 received consolidation with 7+3 followed by mitoxantrone+etoposide. For patients with intermediate-r...

journal_title：Leukemia research

authors： Hassanein M,Atenafu EG,Schuh AC,Yee KW,Minden MD,Schimmer AD,Gupta V,Brandwein JM

更新日期：2013-05-01 00:00:00

abstract：:Imatinib is a highly effective drug for the treatment of chronic myeloid leukemia (CML) that targets the BCR-ABL kinase. However, a number of patients have CML that is resistant to Imatinib treatment. In this report, we developed AGM130 as a potential therapeutic drug for Imatinib-resistant CML treatment. The AGM130 c...

journal_title：Leukemia research

authors： Kim WS,Lee MJ,Kim DH,Lee JE,Kim JI,Kim YC,Song MR,Park SG

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Little is known on racial differences in patients with diffuse large B-cell lymphoma (DLBCL). The aim of this retrospective study is to compare characteristics, prognostic factors and outcomes of Asian and Western patients with DLBCL treated with rituximab, cyclophosphamide, doxorubicin, vincristine and pred...

journal_title：Leukemia research

authors： Castillo JJ,Sinclair N,Beltrán BE,Song MK,Ilic I,Leppa S,Nurmi H,Seki R,Uccella S,Li JM,Treaba DO,Stachurski D,Butera JN

更新日期：2013-04-01 00:00:00

abstract：:c-Myc has been implicated in a variety of hematologic malignancies including Burkitt's lymphoma. Targeting c-Myc driven growth pathways could be therapeutically useful but might require the identification of critical downstream proteins. Here we show that the serine-threonine kinase PBK/TOPK is frequently overexpresse...

journal_title：Leukemia research

authors： Hu F,Gartenhaus RB,Zhao XF,Fang HB,Minkove S,Poss DE,Rapoport AP

更新日期：2013-04-01 00:00:00

abstract：:This study focuses on the effect of chemotherapy on endocrinopathies and the metabolic syndrome in adult survivors of childhood acute myeloid leukemia (AML). Endocrine function and metabolic syndrome were evaluated in 12 AML survivors, treated with chemotherapy, and in 9 survivors of myeloid leukemias treated with ste...

journal_title：Leukemia research

authors： Blijdorp K,van Waas M,van der Lely AJ,Pieters R,van den Heuvel-Eibrink M,Neggers S

更新日期：2013-04-01 00:00:00

abstract：:Chronic myeloid leukemia (CML) is associated with overexpression of BCR-ABL1, a nonreceptor tyrosine kinase critical for malignant transformation. We investigated whether non-coding microRNAs (miRNAs) targeting BCR-ABL1 mRNA contribute to the pathogenesis of CML. Indeed, miR-30a targeted BCR-ABL1 and was underexpresse...

journal_title：Leukemia research

authors： Liu Y,Song Y,Ma W,Zheng W,Yin H

更新日期：2013-03-01 00:00:00

abstract：:Activating mutations of the c-kit gene are frequently found in CBF (core binding factor) leukemias. We evaluated the effect of tyrosine kinase inhibitor dasatinib in leukemic cell lines bearing or not c-kit mutations. Our data demonstrate that in the AML Kasumi-1 cell line, bearing the N822K c-kit mutation, dasatinib ...

journal_title：Leukemia research

authors： Mpakou VE,Kontsioti F,Papageorgiou S,Spathis A,Kottaridi C,Girkas K,Karakitsos P,Dimitriadis G,Dervenoulas I,Pappa V

更新日期：2013-02-01 00:00:00

abstract：:Multiple myeloma (MM) is an incurable plasma cell malignancy, which causes a significant morbidity due to organ damage and bone tissue destruction. In recent years, novel drugs have become available for MM therapy thanks to a more deepened knowledge of this disease's pathogenesis. The perspective of employing targeted...

journal_title：Leukemia research

authors： Piazza F,Manni S,Semenzato G

更新日期：2013-02-01 00:00:00

abstract：:The process of B-cell development is characterized by the activation of the unfolded protein response. Under certain circumstances, the unfolded protein response can be manipulated in a cell death-inducing way. Therefore, tackling the unfolded protein response might be an attractive strategy in the treatment of diffus...

journal_title：Leukemia research

authors： Boelens J,Jais JP,Vanhoecke B,Beck I,Van Melckebeke H,Philippé J,Bracke M,Jardin F,Brière J,Leroy K,Offner F,Lust S

更新日期：2013-01-01 00:00:00

abstract：:Most clinicians caring for patients with AML do not use the word "cure" casually, since for many patients diagnosed with AML, a state of cure or even of long term survival remains elusive. Analysis of prognostic factors may aid in defining the chance for cure in various AML subtypes, and improvements are required at a...

journal_title：Leukemia research

authors： Liesveld J

更新日期：2012-12-01 00:00:00

abstract：:While MDS was only recently viewed as an orphan disease without any FDA approved therapeutic options, the landscape has changed dramatically with a promise for development of exciting new therapeutics that parallels our growing understanding of the pathobiology of the disease. An array of new agents is entering clinic...

journal_title：Leukemia research

authors： List AF

更新日期：2012-12-01 00:00:00

abstract：:Many patients with multiple myeloma (MM) are elderly (aged >65 years) or unfit, and therefore ineligible for stem-cell transplantation. The novel agents thalidomide, bortezomib, and lenalidomide have shown improved outcomes in these patients. This article discusses the role of continuous therapy in improving patient o...

journal_title：Leukemia research

authors： Palumbo A,Niesvizky R

更新日期：2012-11-01 00:00:00

abstract：:During 2004-2006, two hypomethylating agents (HMAs) were approved for the treatment of myelodysplastic syndromes (MDS) in the United States. We assessed the impact of HMAs on the cost of care and survival of MDS patients, by constructing a cohort of patients who were diagnosed during 2001-2007 (n=6556, age ≥66.5 years...

journal_title：Leukemia research

authors： Wang R,Gross CP,Frick K,Xu X,Long J,Raza A,Galili N,Zikria J,Guan Y,Ma X

更新日期：2012-11-01 00:00:00

abstract：:Protein tyrosine kinase-7 (PTK7) was recently identified as a surface protein expressed on hematopoietic cells. To determine if PTK7 is a useful biomarker in clinical practice for acute leukemia immunophenotyping and detection, we examined the PTK7 expression in human bone marrow and thymic specimens. Our results show...

journal_title：Leukemia research

authors： Jiang G,Zhang M,Yue B,Yang M,Carter C,Al-Quran SZ,Li B,Li Y

更新日期：2012-11-01 00:00:00

abstract：:Clofarabine (CLO), a purine nucleoside analog with promising efficacy in acute myeloid leukemia (AML), inhibits the ribonucleotidereductase, p53R2. We have shown that p53R2 mRNA is up-regulated by decitabine (DEC), another drug with promising activity in AML. We developed a pharmacodynamic model to characterize the in...

journal_title：Leukemia research

authors： Thudium KE,Ghoshal S,Fetterly GJ,Haese JP,Karpf AR,Wetzler M

更新日期：2012-11-01 00:00:00

abstract：:In this study, we estimated the association between the inferred haplotypes in the inflammation, DNA repair, and folate pathways, and developed risk models for Hodgkin lymphoma. The study population consisted of 200 Hodgkin lymphoma cases and 220 controls. A susceptible association was observed on the XPC gene with ha...

journal_title：Leukemia research

authors： D'Amelio AM Jr,Monroy C,El-Zein R,Etzel CJ

更新日期：2012-11-01 00:00:00

abstract：:A double monoclonal component (MC) detected in the serum and/or urine represents a very rare occurrence (2-6% of monoclonal gammopathies). In this study, we report 34 patients with double serum MCs, focusing on the associated diseases. The diagnosis was made using high-resolution serum protein electrophoresis and immu...

journal_title：Leukemia research

authors： Guastafierro S,Ferrara MG,Sica A,Parascandola RR,Santangelo S,Falcone U

更新日期：2012-10-01 00:00:00

abstract：:Angiogenesis is a complex process controlled by the balance of a large number of regulating factors, the pro- and anti-angiogenic factors. Dysregulation of angiogenesis occurs in various pathologies and is one of the hallmarks for cancer. Recent emphasis on the microenvironment's influence in chronic lymphocytic leuke...

journal_title：Leukemia research

authors： Xia Y,Lu RN,Li J

更新日期：2012-10-01 00:00:00

abstract：:We retrospectively assessed morphologic and cytogenetic responses to 5-azacytidine and decitabine in a cohort of 42 adult therapy-related myelodysplastic syndromes (tMDS) patients treated at Memorial Sloan-Kettering Cancer Center and in 2 industry-sponsored decitabine trials (D0007 and DACO-020). The overall response ...

journal_title：Leukemia research

authors： Klimek VM,Dolezal EK,Tees MT,Devlin SM,Stein K,Romero A,Nimer SD

更新日期：2012-09-01 00:00:00

abstract：:p23 is a heat shock protein 90 (Hsp90) cochaperone that plays a significant role in estrogen receptor (ER) alpha signal transduction and telomerase activity; it is up-regulated in several cancers. Recent studies have found that high level of p23 may promote tumor progression and poor prognosis in breast cancer patient...

journal_title：Leukemia research

authors： Liu X,Zou L,Zhu L,Zhang H,Du C,Li Z,Gao C,Zhao X,Bao S,Zheng H

更新日期：2012-09-01 00:00:00

abstract：:Determination of T-cell clonality has an important additional value for diagnosis of T-cell lymphomas. Various molecular methods have been developed, including polymerase chain reaction (PCR) of T-cell receptor γ (TCRγ). The detection of PCR products usually relies commonly on either GeneScan (GS) analysis or heterodu...

journal_title：Leukemia research

authors： Beaufils N,Ben Lassoued A,Essaydi A,Dales JP,Formisano-Tréziny C,Bonnet N,Grob JJ,Gabert J

更新日期：2012-09-01 00:00:00

abstract：:Imatinib mesylate, a Bcr/Abl tyrosine kinase inhibitor, is widely used in treating chronic myeloid leukemia. However, drug-resistance of leukemia cells becomes an emergent problem. Herein, various flavonoids were screened for applicability in leukemia treatment, and 3-hydroxyflavone (3-HF) was found to be most effecti...

journal_title：Leukemia research

authors： Kim JH,Song M,Kang GH,Lee ER,Choi HY,Lee C,Kim JH,Kim Y,Koo BN,Cho SG

更新日期：2012-09-01 00:00:00

abstract：:This study was aimed to illustrate the significance of minimal residual disease (MRD) assessment on day 22 in childhood acute lymphoblastic leukemia. MRD were measured on day 22, day 36, week 12, month 6 and month 12 by four-color flow cytometry. The 5-year cumulative incidence of relapse was significantly different f...

journal_title：Leukemia research

authors： Xu XJ,Tang YM,Shen HQ,Song H,Yang SL,Shi SW,Xu WQ

更新日期：2012-08-01 00:00:00

abstract：:We examined the effect of deferasirox (DFX) on CD34+ hematopoietic progenitors from MDS patients. Progressive, dose-dependent suppression of MDS progenitor proliferation in culture was observed with DFX concentrations ranging from 5 μM to 20 μM. This effect was more pronounced in MDS compared to CD34+ progenitors isol...

journal_title：Leukemia research

authors： Pullarkat V,Sehgal A,Li L,Meng Z,Lin A,Forman S,Bhatia R

更新日期：2012-08-01 00:00:00

abstract：:Spider venoms are a rich source of bioactive compounds with therapeutic potential. In traditional Chinese medicine, spiders and spider venoms have been used in the treatment of various ailments. In the present study, the venom of the spider Macrothele raveni potently suppressed cell growth in the myelogenous leukemia ...

journal_title：Leukemia research

authors： Liu Z,Zhao Y,Li J,Xu S,Liu C,Zhu Y,Liang S

更新日期：2012-08-01 00:00:00

abstract：:To improve the recovery rate of high-risk patients with acute promyelocytic leukemia (APL), we used all-trans retinoic acid (ATRA)/arsenic trioxide (ATO)/daunorubicin combination in remission induction, daunorubicin and cytarabine in consolidation, and ATRA/ATO/methotrexate ± 6-mercaptopurine in maintenance treatment ...

journal_title：Leukemia research

authors： Huang H,Qin Y,Xu R,You X,Teng R,Yang L,Xu M,Liu H

更新日期：2012-07-01 00:00:00

abstract：:The studies aimed at identifying a prognostic significance of angiogenesis-related factors: CD105 and placental growth factor (PlGF) in a course of acute lymphoblastic leukaemia (ALL). Research protocol was based on detection of RNA and protein expressions in bone marrow blasts using quantitative PCR and immunocytoche...

journal_title：Leukemia research

authors： Sujka-Kordowska P,Malinska A,Ostalska-Nowicka D,Zabel M,Nowicki M

更新日期：2012-07-01 00:00:00

abstract：:This study uses single cell network profiling (SCNP) to characterize biological pathways associated with in vitro resistance or sensitivity to chemotherapeutics commonly used in acute myeloid leukemia (AML) (i.e. cytarabine/daunorubicin, gemtuzumab ozogamicin (GO), decitabine, azacitidine, clofarabine). Simultaneous m...

journal_title：Leukemia research

authors： Rosen DB,Cordeiro JA,Cohen A,Lacayo N,Hogge D,Hawtin RE,Cesano A

更新日期：2012-07-01 00:00:00

abstract：:Human lymphocyte antigen-G (HLA-G) is an immunosuppressive molecule that induces functional silencing of immune component cells and can be responsible for immunosuppression in patients with multiple myeloma (MM). Immune dysfunction is an important feature of MM and leads to infections as well as may promote disease pr...

journal_title：Leukemia research

authors： Wlasiuk P,Stec A,Piechnik A,Kaminska W,Dmoszynska A,Ksiazek A,Giannopoulos K

更新日期：2012-07-01 00:00:00

abstract：:The aims were to investigate the feasibility of imatinib mesylate (IM) discontinuation in chronic myeloid leukemia patients who were initially treated with IM and achieved complete molecular response (CMR). Fourteen patients were included. Ten were relapsed within 9.5 months after discontinuation of IM. All 7 patients...

journal_title：Leukemia research

authors： Yhim HY,Lee NR,Song EK,Yim CY,Jeon SY,Shin S,Kim JA,Kim HS,Cho EH,Kwak JY

更新日期：2012-06-01 00:00:00

abstract：:Twenty-two patients with myelodysplastic syndromes (MDS) were treated with thalidomide plus arsenic trioxide (ATO). Twenty-two MDS patients receiving supportive care were used as controls. The remission was achieved in 4 patients (18.2%) receiving thalidomide/ATO, and none in the control group (p<0.05). Fifteen of 22 ...

journal_title：Leukemia research

authors： Wei W,Zhou F,Zhang Y,Guo L,Shi H,Hou J

更新日期：2012-06-01 00:00:00

abstract：:Increasing evidence suggest that epigenetic mechanisms (e.g. histone modification by histone deacetylases) play a major role in the pathogenesis of Hodgkin's lymphoma (HL). We treated HL cell lines with the histone deacetylase inhibitor vorinostat and investigated the gene expression profile of these cells by using DN...

journal_title：Leukemia research

authors： Kewitz S,Bernig T,Staege MS

更新日期：2012-06-01 00:00:00